Jacob Wheatley Myerson1, Li He2,
Douglas M. Tollefsen2, Samuel A. Wickline1,2
1Biomedical Engineering, Washington
University, Saint Louis, MO, United States; 2Department of
Medicine, Washington University, United States
Perfluorocarbon
nanoparticles were functionalized with the direct thrombin inhibitor PPACK.
PPACK nanoparticles outperformed heparin in stopping acute thrombosis in
mice. The particles had high affinity and specificity for thrombin and were
visible with 19F magnetic resonance spectroscopy and imaging. PPACK
nanoparticles are proposed a first-in-class anticoagulant with intrinsic
magnetic resonance contrast, concentrated therapeutic impact defined by a
thrombin-absorbing particle surface, and pharmacokinetics optimized by the
base particle.