Jacob Wheatley Myerson1, Megan M. Kaneda1, Gregory M. Lanza1,2, Samuel A. Wickline1,2
1Biomedical Engineering, Washington University, Saint Louis, MO, United States; 2Department of Medicine, Washington University, Saint Louis, MO, United States
Perfluorocarbon nanoparticles were functionalized to deliver VCAM-1 siRNA to human melanoma cells. Delivery was quantified via 19F magnetic resonance spectroscopy. For future in vivo studies, an MR-trackable delivery agent would aid in the determination of localization of siRNA delivery to specific tissues.