Abstract #1004

The 17O Imaging for Regional Oxygen Consumption Rate in Tumor Bearing Mice at 7T

Michiko Narazaki¹, Yoko Kanazawa², Hiroo Ikehira², Tetsuya Matsuda¹

¹Kyoto University, Kyoto, Japan; ²National Institute of Radiological Sciences, Chiba, Japan

The tumor oxygen consumption rate in mice using ¹⁷O images was investigated. ¹⁷O FISP images were acquired before and after the inhalation of ¹⁷O enriched oxygen gas. The increment in the ¹⁷O image intensity due to the metabolically generated H₂¹⁷O from ¹⁷O₂ was converted to the quantity of produced H₂¹⁷O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.