Ilya Michael Nasrallah1, Sungheon Kim2, Ranjit Ittyerah1, Stephen Pickup1, John H. Wolfe3,4, Harish Poptani1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2New York University; 3Departments of Pathobiology and Pediatrics, University of Pennsylvania; 4Children's Hospital of Philadelphia
Mucopolysaccharidosis Type VII (MPS VII) is one of the degenerative lysosomal storage diseases characterized by intracellular vacuolization. Using high-resolution MRI in a mouse model of MPS VII with manual segmentation, we identify decreases in corpus callosum and anterior commisure volume and slight increase in hippocampus volume in mutant mice. A decrease in corpus callosum volume thickness is confirmed at histology. These parameters could be used for monitoring experimental response to gene therapy treatments.