Michael Neumaier1, Elmar Schuck2, Thomas Kaulisch1, Heiko G. Niessen1, Dieter Klatt3, Ingolf Sack3, Juergen Braun4, Detlef Stiller1
1In-Vivo Imaging Unit, Dept. of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany; 2Precision Mechanics, Dept. of Site Operations, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany; 3Dept. of Radiology, Charit - University Medicine Berlin, Berlin, Germany; 4Dept. of Medical Informatics, Charit - University Medicine Berlin, Berlin, Germany
MR elastography (MRE) is a powerful tool for the non-invasive assessment of liver diseases. It requires the reliable delivery of shear waves in the acoustic frequency range between 25 and 1000 Hz. We present a novel concept of motion generation suitable for MRE of small animals based on a piezoelectric wave generator and a hydraulic transmission system. The new system provides excellent wave penetration of rat liver in the desired frequency range and yields reproducible and consistent results.