Najmeh Khalili-Mahani1,2, Mathiass J. P. Van Osch1, Remco W. M Zoethout3, Evelinda Baerends1, Mark A. Van Buchem1, Joop M. A. Van Gerven3, Serge A. R. B. Rombouts1,2
1Leiden University Medical Center, Department of Radiology, Leiden, Netherlands; 2Leiden Institute for Brain and Cognition, Department of Psychology, Leiden, Netherlands; 3Center for Human Drug Research, Leiden University Medical Center, Leiden, Netherlands
In a within-subject placebo-controlled pharma-fMRI study, we use pseudo-continuous ASL to show localized and drug-specific changes in CBF in response to dose-controlled infusion of morphine and alcohol. Results correspond to variations observed in the resting-state BOLD fluctuations in the same study.