Deepa Prajapati1, Sundeep Tripathi2, Sanjay Annarao1, Abbas Ali Mahdi2, Mahdi Hasan3, Farzana Mahdi4, Raja Roy1, Chunni Lal Khetrapal1
1CBMR, Centre of Biomedical Magnetic Resonance, Lucknow, Uttar Pradesh, India; 2CSM Medical University; 3Anatomy, CSM Medical University; 4Era's Lucknow Medical College
Prolonged aluminium insults results in oxidative damage leading to hepato and nephrotoxicity in rats.1H NMR study of rats serum and urine have been utilized to evaluate the comparative protective effects of Bacosides and Donepezil drugs over continuous Aluminium- induced metabonomic changes. Bacosides was found to markedly attenuate the oxidative stress induced by Aluminium over long term (90 days) dose compared to Donepezil. This might be interpretated in terms of strong antioxidative property of Bacosides compared to Donepezil. The study suggests that 1H NMR metabolic profiling is an efficient method to explore the efficacy of potent molecules over metal toxicity.