Robert L. Barry1,2, J Christopher Gatenby1,2, Allen T. Newton1,2, Stephen C. Strother3,4, John C. Gore1,2
1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 3Rotman Research Institute of Baycrest, Toronto, ON, Canada; 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Although 2D single-shot EPI is common in BOLD fMRI, recent studies have suggested that 3D multi-shot sequences such as PRESTO-SENSE may offer superior BOLD CNR through improved temporal efficiency. A four-way comparison was performed between 2D and 3D acquisition sequences at two voxel resolutions (1.19x1.19x2 mm3 and 2.19x2.19x2 mm3) at 7T. The quality of fMRI data was evaluated via independent and unbiased metrics of prediction and reproducibility using NPAIRS. Results suggest that EPI provides higher prediction and reproducibility for this study. Future work will investigate within-subject optimization, and further compare EPI with PRESTO-SENSE for an fMRI study requiring whole-brain coverage.