Karsten Mueller1, Toralf Mildner1, Tom Fritz1, Joeran Lepsien1, Christian Schwarzbauer2, Harald E. Mller1
1Max Planck Institute for Human
Cognitive and Brain Sciences,
To present auditory stimuli in the absence of scanner noise, the sparse temporal sampling (STS) approach was introduced. The interleaved-silent steady-state (ISSS) technique is combining the idea of splitting image acquisition and stimulus presentation with a better sampling of the fMRI signal. We performed an auditory experiment with pleasant and unpleasant stimuli using four fMRI sessions: STS, ISSS, and simultaneous stimulus presentation and image acquisition with axial and sagittal scanning. The total acquisition time was the same in all four sessions. The best sensitivity for detecting activations of sub-cortical regions (such as the amygdala) was found for ISSS.