Oliver Hinds1, Aaron Hess2, M. Dylan Tisdall3, Todd Thompson1, Hans Breiter3, Andr van der Kouwe3
1A. A. Martinos Imaging Center at the McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, United States; 2Human Biology, University of Cape Town, Cape Town, South Africa; 3A. A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA, United States
If the BOLD response to EPI acoustic noise changes over the time course of a standard fMRI experiment, both Type I and Type II errors can be made in fMRI group analysis. We used a pulse sequence based on single-voxel functional spectroscopy to silently measure the BOLD response induced by EPI-like scanner noise over about 40 minutes. No significant habituation or facilitation with respect to the scanner noise was found over that time. This result eliminates a possible confound for auditory and speech neuroimaging studies, especially those involving learning.