Jan Mehnert1,2, Christoph Schmitz2,3, Harald E. Mller1, Hellmuth Obrig1,2, Karsten Mller1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Berlin Neuroimaging Center, Charit University Hospital Berlin, Berlin, Germany; 3NIRx Medizintechnik GmbH, Berlin, Germany
Correlation analysis of low-frequency fluctuations in blood-oxygen level dependent (BOLD) fMRI data is known to yield functional connectivity maps. The procedure, also referred to as resting-state connectivity, has previously been applied to optical tomography (OT) data using dense probe arrays. Here, we assess whether a sparser topographical sampling still yields results that are comparable to the gold standard of resting-state network assessment, i.e. fMRI. In a first step, we used a subset of optical fibers (2-3cm inter-optode distance) covering both motor cortices and combined OT with concurrent fMRI measurements to cross-validate our resting-state data analysis.