Matthew Borzage1,2, Marvin Nelson3, Istvan Seri1,4, Stefan Blml3,5
1Neonatal Medicine, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 2Viterbi School of Engineering, University of Southern California, Los Angeles, 90007, United States; 3Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 4Keck School of Medicine, University of Southern California, Los Angeles, CA, United States; 5Rudi Schulte Research Institute, Santa Barbara, CA, United States
Studying changes in cerebral hemodynamics is possible via MR, including blood oxygen level dependent (BOLD) imaging. We used near infrared spectroscopy (NIRS) to sample oxy- and deoxyhemoglobin directly, and utilized a nitrogen challenge to change FiO2 and thus cause measurable changes in blood oxygenation. We have observed good correlation between the BOLD and NIRS signals, with higher correlation in the gray matter than in the white matter. In the near future, we will use this paradigm to study the limited autoregulation of cerebral blood flow in preterm neonates.