Clarisse Ildiko Mark1, M. Slessarev2,
1McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; 2Department of Anaesthesiology, University Health Network, Univeristy of Toronto,, Toronto, Ontario, Canada; 3Department of Anaesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Manual HC calibration depends on intrinsically low signal-to-noise perfusion imaging and individual vascular architecture, with resulting calibration (M)-values prone to large intra- and inter-subject variations that may bias oxygen metabolism studies. We thereby sough to investigate HO as a calibration alternative under rigorous control of end-tidal partial pressures of CO2 (PetCO2) and O2 (PetO2). Our findings suggest the viability of precisely controlling HO stimulation to provide more precise per-subject and per-brain-region M-estimates, based on high SNR PaO2 measurements and the removal of the confound of vascular variation in population observed under HC-calibration.