Dewen Yang1, Zhiyong Xie1, James
Goodman1, Anne Burkholder2,
1BioImaging COE, Pifizer Global Research & Development, Groton, CT, United States; 2WW Comparative Medicine, Pifizer Global Research & Development, Groton, CT, United States
The neurovascular response to electric forepaw stimulation (EFS) was observed with BOLD signal in the contralateral somatosensory cortex in 11 rats with normal blood gas physiology under alpha-chloralose anesthesia. Serial CBF maps were also acquired during EFS in a subset of these rats. BOLD activation and CBF maps showed elevated blood flow in the contralateral somatosensory cortex at the time of stimulation, after which the regional activation and increases in CBF spread to cortex in the ipsilateral hemisphere.