Xiao Wang1, Xiao-hong Zhu1, Yi Zhang1, Wei Chen1
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States
The feasibility of saturation-recovery T1 MRI for imaging and quantifying absolute CBF change was further tested at 9.4T using a rat hypercapnia model on two aspects: using diffusion gradients to investigate macrovascular inflow contribution; and slab saturation with varied thickness to test the effects of blood transit distance on measuring CBF. The results indicate that the outcomes of CBF changes induced by hypercapnia were coincident with the literature reports, and not significantly affected by large-vessel inflow effect and blood transit time. The overall results demonstrate that the saturation-recovery T1 MRI is sensitive to microvascular perfusion; it provides a noninvasive and reliable imaging approach for studying cerebral perfusion changes induced by physiology or pathology perturbation.