Andrew James Patterson1, Tjun Y. Tang1, Martin J. Graves1, Simon P. S. Howarth1, Jonathan H. Gillard1
Previous studies have reported Ultra-Small Super-Paramagnetic Iron Oxide (USPIO) detected inflammation in carotid atherosclerotic disease using a semi-quantitative analysis technique that involves measuring changes in signal intensity relative to adjacent muscle tissue. In this study an alternative method to detect and quantify changes over-time is presented. The methodology involved making direct quantitative T2* measurements within the atherosclerotic plaque pre- and post- infusion. In a double blinded randomised control trail this study measured a significant difference (p<0.001) with respect to time in USPIO-detected inflammation between patients receiving low-dose and high-dose statin therapy.