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Abstract #1270

Measurement of the Mean ADC Values of Lipid, Hemorrhage and Overall Wall Components Using In-Vivo Human Carotid Artery Diffusion Weighted Imaging

Seong-Eun Kim1,2, Scott McNally2, Laura K. Findeiss2, Jordan Hulet3, John Roberts1,2, Eun-Kee Jeong1,2, Dennis L. Parker1,2, Gerald S. Treiman4,5

1UCAIR, University of Utah, Salt Lake City, UT, United States; 2Department of Radiology, University of Utah, Salt Lake City, UT, United States; 3Department of Biomedical Informatics, University of Utah; 4Department of Surgery, University of Utah, Salt Lake City, UT, United States; 5Veterans Affair, VASLCHCS, Salt Lake City, UT, United States


Atherosclerotic plaques are composed of varying degrees of lipid, necrotic tissue, loose connective tissue, hemorrhage, and calcification. The extent of lipid accumulation and the presence of intramural hemorrhage have been found to be associated with the degree of plaque vulnerability and risk of plaque rupture. Recent ex vivo studies of carotid plaques found that DWI could detect lipids and hemorrhage with greater sensitivity than other MRI. This study reports the ADC values of lipid, hemorrhage and overall wall composition as measured with in-vivo DWI, with histology used as the basis for comparison