Jens T. Rosenberg1,2, Sara Campbell3, Ihssan Masad, 12, Bahram H. Arjmandi3, Samuel Colles Grant, 12
1CIMAR, The National High Magnetic Field Laboratory, Tallahassee, FL, United States; 2Chemical and Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 3Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, FL, United States
Ovariectomized (ovx) hamsters provide a model of postmenopausal atherosclerosis to investigate plaque formation in cerebral and systemic vasculature. The anti-atherogenic effects of flaxseed were studied by measuring the diameter of vessels using high resolution images acquired at high field (21.1 T). The animals were imaged at three time points: baseline, 4 months and 8 months. Atherosclerotic plaque formations were compared between sham, ovx, and ovx-flaxseed treated animals. No occlusions could be seen in cerebral arteries while differences were identified in the carotids and system circulation.