Jose Manuel Morales1, Fabian Chaustre2,
David Moratal3, Vicent Bodi4, Daniel Monleon2
1Universitat de Valencia, Valencia,
Spain; 2Fundacion Investigacion Hospital Clinico Valencia,
Valencia, Spain; 3Center for Biomaterials and Tissue Engineering,
Universitat Politecnica Valencia, Valencia, Spain; 4Hospital
Clinico Universitario de Valencia, Valencia, Spain
The
protocols of management of patients entering emergency rooms because thoracic
pain of potential ischemic origin without necrosis include serial measurement
s of biomarkers, stress tests and, in many cases, unnecessary
hospitalization. In this context, detection of metabolic markers, which
represent dynamic changes in just a few minutes after ischemia, is an
attractive option both for diagnosis precision and for rapid and efficient
management. In this communication, we used NMR metabolic profiling to
characterize metabolically blood plasma of patients pre and post angioplasty.
Statistical multivariate analysis showed differences in signals belonging
mainly to ketonic bodies and fatty acids.