Walter RT Witschey1,2, James J. Pilla2, Giovanni Ferrari2, Keivn Koolmasingh2, Mohammed Haris1, Robin Hinmon2, Gerald A. Zsido1, Joseph H. Gorman III2, Robert C. Gorman2, Ravinder Reddy1
1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States
T1ρ MRI was performed to differentiate scar tissue, proximal, borderzone tissue and healthy myocardium in a swine model of left ventricular myocardial infarction. The spatially-dependent relaxation times were validated by histological staining of collagen and myocytes. Significant magnetic relaxation dispersion with the application of a varying amplitude RF field was observed. These results suggest that T1ρ is superior to conventional methods such as T2 for the visualization of early edema and late scarring and expansion in patients with ischemic cardiomyopathy.