Nilesh R. Ghugre1, Venkat Ramanan1, Mihaela Pop2, Yuesong Yang1, Jennifer Barry1, Beiping Qiang1, Kim Connelly3, Alexander J. Dick1, Graham A. Wright1,2
1Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada
Pathophysiological responses after acute myocardial infarction (AMI) include edema, hemorrhage and microvascular obstruction (MVO) along with cellular damage. The in vivo evolution of these processes throughout infarct healing has not been well characterized. The purpose of our study was to monitor the time course of edema (T2), hemorrhage (T2*) and MVO in porcine myocardium following AMI and to observe the relative resolution of these pathophysiological mechanisms. Our study suggests that quantitative T2 and T2* mapping techniques are potentially more specific than intensity measures in single images, allowing regional, longitudinal and cross-subject comparisons. Such in vivo characterization will be important in grading severity and evaluating treatment strategies in AMI, potentially improving clinical outcome.