Xiangzhi Zhou1, Veronica Rundell1, Ying Liu1, Richard Tang1, Rachel Klein1, Shivraman Giri2, Saurabh Shah3, Sotirios A. Tsaftaris1, Sven Zuehlsdorff3, Orlando Simonetti2, Debiao Li1, Rohan Dharmakumar1
1Northwestern University, Chicago, IL, United States; 2Ohio State University, Columbus, OH, United States; 3Siemens Medical Solutions USA, Inc., Chicago, IL, United States
The biophysical mechanisms contributing to myocardial edema contrast in T2-weighted STIR images was studied using dogs subjected to ischemia-reperfusion injury. It is shown that in addition to T2-weighting, edema detection in acute myocardial infarcts with T2-weighted STIR images have substantial weighting from proton density changes. This finding suggests that myocardial edema detection sensitivity is enhanced when acquisition strategies permit sensitivity to proton density, as well as T2 changes.