Jiongjiong Wang1, Xiaoming Bi2,
Tongbai Meng3, Sven Zuehlsdorff2, John A. Detre4
1Radiology, University of Pennsylvania,
Philadelphia, PA, United States; 2Cardiovascular MR R&D,
Siemens Healthcare, Chicago, IL, United States; 3Center for
Applied Medical Imaging, Siemens Corporate Research, Baltimore, MD, United
States; 4Neurology, University of Pennsylvania, Philadelphia, PA,
United States
Arterial
spin labeling (ASL) has been applied for noninvasive measurement of
myocardial blood flow (MBF), yet the reliability is not optimal due to the requirement
for repeated breath holding. We developed a cardiac ASL technique for
reliable clinical applications dubbed FREE-breathing Myocardial ASL with
Navigator-echo (FREEMAN). Dynamic myocardial perfusion signals were measured
at multiple delays. The estimated mean MBF was 10356ml/100g/min with a mean
transit time of approximately 400ms and moderate to high test-retest
reliability.