Jiongjiong Wang1, Xiaoming Bi2, Tongbai Meng3, Sven Zuehlsdorff2, John A. Detre4
1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, United States; 3Center for Applied Medical Imaging, Siemens Corporate Research, Baltimore, MD, United States; 4Neurology, University of Pennsylvania, Philadelphia, PA, United States
Arterial spin labeling (ASL) has been applied for noninvasive measurement of myocardial blood flow (MBF), yet the reliability is not optimal due to the requirement for repeated breath holding. We developed a cardiac ASL technique for reliable clinical applications dubbed FREE-breathing Myocardial ASL with Navigator-echo (FREEMAN). Dynamic myocardial perfusion signals were measured at multiple delays. The estimated mean MBF was 10356ml/100g/min with a mean transit time of approximately 400ms and moderate to high test-retest reliability.