Nilesh R. Ghugre1, Venkat Ramanan1, Mihaela Pop2, Yuesong Yang1, Jennifer Barry1, Beiping Qiang1, Kim Connelly3, Alexander J. Dick1, Graham A. Wright1,2
1Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada
Coronary vasodilatory dysfunction has been shown in infarcted as well as remote myocardium in patients with acute coronary syndrome. Our study demonstrates the utility of T2-based BOLD effect in probing regional and longitudinal fluctuations in vasodilatory function in a porcine model of myocardial infarction at 3T. T2 measurements were performed in remote and infarcted myocardium at rest and after Dipyridamole-induced vasodilation (stress). Experimental observations indicated that T2 at 3T offers greater sensitivity towards detecting changes in myocardial oxygenation compared to 1.5T, consistent with a two-compartment theoretical model. Stress-induced vasodilatory response using quantitative T2 can help evaluate remote-zone vascular function and potentially identity salvageable myocardium in the infarct zone.