Valentina Taviani1, Stacey S. Hickson2,
Christopher J. Hardy3, Andrew James Patterson1,
1Department of Radiology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; 2Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; 3GE Global Research, Niskayuna, NY, United States
Age-related changes of regional aortic compliance play a crucial role in the pathophysiology of cardiovascular disease. Fourier velocity encoded (FVE) M-mode can produce Doppler-like time-velocity traces with high temporal and spatial resolution along relatively straight arterial segments. In this work, FVE M-mode was used to measure global and regional pulse wave velocity (PWV) in the descending aorta of 56 healthy subjects. A significant nonlinear relationship between overall PWV and age was found (r2=0.73, p<0.001). The distal thoracic aorta was found to stiffen the most with age, followed by the proximal and distal abdominal aorta.