Tobias Saam1, Thomas Pfefferkorn2, Maximilian Habs1, Marcus Hacker3, Axel Rominger3, Clemens C. Cyran1, Martin Dichgans2, Maximilian F. Reiser1, Konstantin Nikolaou1
1Clinical Radiology, University of Munich, Munich, Bavaria, Germany; 2Neurology, University of Munich, Munich, Bavaria, Germany; 3Nuclear Medicine, University of Munich, Munich, Bavaria, Germany
Spontaneous cervical artery dissection (sCAD) is a frequent cause of ischemic stroke in young adults. The pathogenesis of sCAD is poorly understood. The aim of this study was to use PET/CT and MRI to estimate the prevalence of perivascular inflammation in sCAD. This study demonstrates that inflammatory changes at the site of the arterial dissection are common in sCAD patients. In a subset of these patients, perivascular inflammation was not confined to the site of the dissection, suggesting that vessel wall inflammation might play a role in the pathogenesis of sCAD.