Yasuyoshi Kuroiwa1,2, Atsushi Yamashita3, Tosiaki Miyati1, Eiji Furukoji4, Misaki Takahashi3, Toshiya Azuma4, Hiroshi Sugimura4, Shozo Tamura4, Keiichi Kawai1,5, Yujiro Asada3
1Division of Health Sciences, Graduate School of Health Science, Kanazawa University,, Kanazawa, Ishikawa, Japan; 2Department of Pathology, , Faculty of Medicine, University of Miyazaki, Miyazaki, Japan; 3Department of Pathology,, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan; 4Department of Radiology,, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan; 5Biomedical Imaging Research Center, University of Fukui
To determine the potential of MR to detect venous thrombosis and to define thrombus age, we examined in vivo MR imaging of rabbit jugular vein thrombi 4 hours, 1, 2, 4 weeks after endothelial denudation and vessel ligation, and assessed the association between signal intensities and cellular and matrix contents. We demonstrated that MRI can reliably and noninvasively detect rabbit jugular vein thrombi, and that sequential changes in T2 and T1 weighted signal intensity may reflect organizing process of the venous thrombus. MRI may noninvasively detect venous thrombosis and define thrombus age which is valuable information for thrombolytic therapy.