Akira Nabetani1, Masayuki Yamaguchi2, Akira Hirayama1,2, Minoru Mitsuda2,3, Ryutaro Nakagami2,3, Atsushi Nozaki1, Mamoru Niitsu3, Hirofumi Fujii2,4
1GE Healthcare Japan, Ltd., Hino, Tokyo, Japan; 2Functional Imaging Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; 3Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa, Tokyo, Japan; 4Institute for Bioinformatics Research and Development Japan Science and Technology Agency, Chiyoda, Tokyo, Japan
We constructed and tested a new multiple-animal magnetic resonance imaging (MRI) device that uses a 3-Tesla (3-T) whole-body scanner. An array coil comprising 16 small circular coils was connected to 16 preamplifiers and receivers of the scanner. This device can be used to perform simultaneous whole-body scanning of 4 rats or 16 mice. This approach facilitates progress in preclinical MRI and may be helpful in pharmaceutical drug-development studies in which various doses of multiple compounds are assessed in a large number of animals.