Huiling Peng1, Jewell Thomas1,
Joseph Mettenburg2, Avi Snyder1, Tammie Benzinger2,
David Clifford1, Robert Paul3, Beau Ances4
1Neurology, Washington University in
St. Louis, St. Louis, MO, United States; 2Radiology, Washington
University in St. Louis, St. Louis, MO, United States; 3Psychology,
University of Missouri St. Louis, St. Louis, MO, United States; 4Neurology,
Washington University in St. Louis, St. Louis, MO , United States
Hepatitis
C virus (HCV) is a frequent co-infection with HIV. Both affect brain function
raising the possibility of synergistic interactions. We investigate the
relationship between neurological function and white matter integrity using
DTI in mono (HIV+) (n=15) vs. co-infected (HIV+/HCV+) (n=13) participants.
Regions-of-interest corresponding to the cingulum and genu of the corpus
callosum were selected. Co-infected participants were more impaired than
mono-infected HIV+ subjects on neuropsychological testing but no significant
differences were seen for DTI values.
The combination of HIV and HCV co-infection affected measures within
the brief neurocognitive screening but not structural neuroimaging measures.