Torben Schneider1, Henrik Lundell2,3, Tim B. Dyrby2, Daniel C. Alexander4, Claudia Angela Michela Wheeler-Kingshott1
1NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark; 3Department of Excercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark; 4Centre for Medical Image Computing, Department of Computer Science, UCL, London, United Kingdom
We present a method that optimizes diffusion MRI protocols to be sensitive to axon diameter and axonal density in white matter structures with known single fibre direction. Computer simulations clearly show that our method improves accuracy of measurements compared to protocols independent of fibre orientation, especially when signal-to-noise-ratio is low. Furthemore, we generate indices of axon diameter and density from a fixated monkey spinal cord and are able to discriminate anatomically different white matter regions.