Influence of Holmium-166 Loaded Microspheres on ADC Measurements Using DWI
Hendrik van de Maat1, Peter R. Seevinck1, Chris J.G
1Image Sciences Institute, Utrecht, Netherlands;
2Department of Radiology, University
was shown that the presence of HoMS attenuates
the signal of diffusion weighted images leading to a ADC reduction of 0.1mm2/ms
per mg/ml HoMS.
The reduction of the ADC is caused by the additional gradients induced by the
microspheres resulting in a additional weighting factor for calculation of
the ADC which is not taken into account. The dependency of the ADC on
is an effect that should be considered when using DWI for evaluating tumor
viability after radioembolization. Since the local concentration can range up
to 15mg/ml, a potential underestimation of the ADC of 1.5mm2/ms
can occur which may lead to wrong diagnostic conclusions.