Eleftheria Panagiotaki1, Matt G. Hall1, Bernard Siow1,2, Mark F. Lythgoe2, Daniel C. Alexander1
1Centre for Medical Image Computing, Dept. of Computer Science, University College London, London, United Kingdom; 2Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom
This work outlines a method to construct detailed three-dimensional geometric models of tissue microstructure using confocal laser scanning microscopy (CLSM) images. We use these models to simulate the diffusion MRI signal from the tissue by running random-walk simulations within the resulting mesh. The precise simulated data from our method provide a mechanism for evaluating the quality of simple parametric models and the parameter estimates they provide.