Yu-Chien Wu1, Charles A. Mistretta2, Andrew L. Alexander3, Trevor Andrews4, Paul J. Whalen5, James V. Haxby5
1Dartmouth Brain Imaging Center, Dartmouth College, Hanover, NH, United States; 2Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, United States; 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 4College of Medicine, University of Vermont, Burlington, VT, United States; 5Psychological & Brain Sciences, Dartmouth College, Hanover, NH, United States
High angular resolution diffusion imaging (HARDI) has drawn considerable attention for its powerful directional measure on predicting fiber orientation at the level of subvoxel dimension. HARDI may improve the accuracy of WM tractography, which leads to an important application of brain structural connectivity. However, due to the higher diffusion weighting (DW) b-value and substantial number of DW directions, its long scan time is often the obstacle for extensive clinical application. In this study, we investigate the feasibility of the new reconstruction method, highly constrained back projection reconstruction, which may significantly reduce HARDI scan time.