Peter Savadjiev1, Marek Kubicki1,
Sylvain Bouix1, Gordon L. Kindlmann2, Martha E. Shenton1,3,
Carl-Fredrik Westin4
1Psychiatry, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA, United States; 2Computer
Science, University of Chicago, Chicago, IL, United States; 3Psychiatry,
VA Boston Healthcare System, , Brockton , MA, United States; 4Radiology,
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United
States
Knowledge
of fibre geometry and its variation along fibre tracts can be useful for the
study of normal and pathological white matter. In this work we present a
tract-based analysis of two recently introduced measures of fibre geometry,
which compute fibre dispersion and fibre curving, directly from a diffusion
tensor field and its gradient. These measures of fibre geometry are mapped
and analysed along a parametric representation of fibre tracts. Such
representations of fibre tract geometry are an important tool for the
understanding of white matter structure.