Hsiao-Ying Wey1, Jinqi Li1, Jiongjiong Wang2, Sung-Hong Park1, Timothy Q. Duong1
1Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States; 2Radiology, University of Pennsylvania, Philadelphia, PA, United States
Quantitative blood flow measurement of the retina is critically important as many retinal diseases could perturb basal blood flow and blood flow responses to stimulations. In this study, we developed and applied the pseudo-continuous ASL to improve ASL contrast, and systematically explored blood-flow MRI of the retina in anesthetized baboon on a human clinical scanner. Anesthetized baboons were used to exclude movement artifacts such that we could focus on evaluating hardware feasibility and imaging parameters for high-resolution quantitative BF imaging of the retina as a first step toward evaluating potential human applications.