Hsiao-Ying Wey1,2, Jinqi Li1,
Lisa Jones3, M Michelle Leland3, C Akos Szabo4,
Jiongjiong Wang5, Peter T. Fox1, Timothy Q. Duong1,2
1Research Imaging Institute, UT Health
Science Center at San Antonio, San Antonio, TX, United States; 2Radiology,
UT Health Science Center at San Antonio, San Antonio, TX, United States; 3Laboratory
Animal Resources, UT Health Science Center at San Antonio, San Antonio, TX,
United States; 4Neurology, UT Health Science Center at San Antonio,
San Antonio, TX, United States; 5Radiology, University of
Pennsylvania, Philadelphia, PA, United States
This
study reports the implementation and optimization of a pseudo-continuous
arterial-spin-labeling technique for non-human primate (baboon) research on a
Siemens 3T TIM-Trio. High-contrast basal cerebral-blood-flow (CBF) images
were obtained in 2 mins at 2x2x5 mm resolution. CBF of gray matter and white
matter was analyzed for two commonly used anesthetics: isoflurane and
ketamine. Moreover, CBF-based fMRI, obtained with a 7-s resolution, showed
robust hypercapnia-induced CBF changes. This technology is expected to
provide a non-invasive means to study physiology, function, and neurovascular
coupling for non-human primate research.