Yue Zhang1, Christopher B. Glielmi, Yin Jiang2, Jing Liu3, Ying Hao4, Xiaoying Wang3,4, Jing Fang, 1,4, Jisheng Han2, Jue Zhang, 1,4, Xiaoping Hu5
1College of Engineering, Peking University, Beijing, China; 2Neuroscience Research Institute, Peking University, Beijing, China; 3Dept.of Radiology, Peking University First Hospital, Beijing, China; 4Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 5Dept. of Biomedical Engineering, Georgia Institute of Technology / Emory University, Atlanta, United States
Blood oxygenation level dependent (BOLD) technique has been used to map brain activity related to electrical acupoint stimulation (EAS) in previous pain-relief studies, but introduces relatively poor reproducibility and consistencies. In this study, the dual-echo based simultaneous acquisition of cerebral blood flow (CBF) and BOLD was employed to provide the first evidence of CBF response to EAS and inter-subjects variation was compared between the two techniques. The results suggested that the sensitivity and specificity to sensory and pain-related regions were consistent with previous findings. Moreover, CBF based inter-subjectsvariation had a significant decrease than BOLD.