Johannes Gregori1,2, Norbert Schuff3,4, Matthias Gnther1,5
1Institute for Medical Image Computing, Fraunhofer MEVIS, Bremen, Germany; 2Neurology, Universittsmedizin Mannheim, Heidelberg University, Mannheim, Germany; 3Radiology & Biomedical Imaging, University of San Francisco, San Francisco, CA, United States; 4Center for Imaging of Neurodegenerate Diseases (CIND), VA Medical Center, San Francisco, CA, United States; 5mediri GmbH, Heidelberg, Germany
We present ASL time series measurements with spin/gradient double echo spiral 3D-GRASE readout to quantify R2' of the ASL difference signal. R2' can give information about blood oxygenation and blood volume, while ASL time series are used to investigate perfusion dynamics. Using the combination of both techniques, we can measure the changes of R2' over different inflow times and discuss the physiological underlyings.