Michael Peller1, Martin Hossann2,
Tungte Wang2,3, Steven Sourbron1, Lars H. Lindner2,3
1Institute of Clinical Radiology,
University Hospital of Munich, Munich, Germany; 2Department of
Internal Medicine III, University Hospital Munich; 3CCG-Hyperthermia,
Helmholtz Zentrum Mnchen, German Research Center for Environmental Health,
Germany
Purpose
was to investigate the dynamics of mild temperature induced contrast agent
release from phosphatidylglyc-eroglycerol containing thermosensitive
liposomes with encapsulated Gd-DTPA-BMA (Gd-TSL) in tumor tissue. Tumor
bearing mice were investigated at 1.5T after intravenous injection. The
temperature induced release of contrast agent at 42C caused a fast and strong
increase of T1-weighted signal. Immediately after i.v. injection heated tumor
tissue was distinguishable from unheated tumor and muscle tissue. Unheated
muscle tissue may thus be less affected by a potential anti tumor therapy
based on TSL.