Michael Peller1, Martin Hossann2, Tungte Wang2,3, Steven Sourbron1, Lars H. Lindner2,3
1Institute of Clinical Radiology, University Hospital of Munich, Munich, Germany; 2Department of Internal Medicine III, University Hospital Munich; 3CCG-Hyperthermia, Helmholtz Zentrum Mnchen, German Research Center for Environmental Health, Germany
Purpose was to investigate the dynamics of mild temperature induced contrast agent release from phosphatidylglyc-eroglycerol containing thermosensitive liposomes with encapsulated Gd-DTPA-BMA (Gd-TSL) in tumor tissue. Tumor bearing mice were investigated at 1.5T after intravenous injection. The temperature induced release of contrast agent at 42C caused a fast and strong increase of T1-weighted signal. Immediately after i.v. injection heated tumor tissue was distinguishable from unheated tumor and muscle tissue. Unheated muscle tissue may thus be less affected by a potential anti tumor therapy based on TSL.