Praveen Kumar Gulaka1, Vikram D. Kodibagkar1,2
1Biomedical Engineering, UT Arlington and UT Southwestern Medical Center at Dallas, Dallas, Tx, United States; 2Radiology, UT Southwestern Medical Center at Dallas, Dallas, Tx, United States
The ability to measure tissue oxygen tension non-invasively may have a significant impact in understanding mechanisms of tissue function and in clinical prognosis of disease. Previous research demonstrated hexamethyldisiloxane (HMDSO) as a 1H based pO2 reporter molecule by in vivo spectroscopy and imaging using Proton Imaging of Siloxanes to map Tissue Oxygenation Levels (PISTOL) technique. We now present in vitro data demonstrating the pO2 calibration curves of linear and cyclic siloxanes of different chain lengths as pO2 sensing reporter molecules for use in conjunction with PISTOL.