Chalermchai Khemtong1, Osamu Togao2, Jimin Ren2, Chase W. Kessinger1, Masaya Takahashi2, A Dean Sherry2, Jinming Gao1
1Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States
Herein, we report the effect of PEG corona lengths on MR relaxivity and ORS sensitivity of SPPM. Results showed that the length of the pegylated shell is a critical physical parameter that controls MR relaxivity and ORS sensitivity of SPPM. SPPM with shorter PEG corona has a higher T2 relaxivity and hence ORS sensitivity. Results from this study provide the fundamental insights on the design of SPPM as ultrasensitive MRI nanoprobes for in vivo molecular imaging applications.