Hisanori Kosuge1, Toshiro Kitagawa1, Takeshi Kobayashi2, Michael V. McConnell1
1Cardiovascular Medicine, Stanford University, Stanford, CA, United States; 2Biological Chemistry, Chubu University, Kasugai, Aichi, Japan
Inflammation plays a critical role in the progression of atherosclerosis. Magnetite liposomes (MLs) have been used for magnetic hyperthermia of cancer cells and for cellular MR imaging. Thus, they may have the potential to both image and treat vascular inflammatory cells. We demonstrate that MLs show macrophage uptake and effective magnetic hyperthermia and cell death in vitro. ML also imaged mouse carotid vascular inflammation by 7T MRI.