Jason A.
Langley1, E Kay Jordan2, Wei Liu3, Joseph A.
Frank2, Qun Zhao1
1Department of Physics and Astronomy,
The University of Georgia, Athens, GA, United States; 2Experimental
Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National
Institutes of Health, Bethesda, MD, United States; 3Phillips
Research, North America, Briarcliff Manor, NY, United States
A
method for quantifying concentrations of SPIO nanoparticles is presented in
this abstract and the proposed method is tested on SPIO-labeled tumors that
were implanted in the flank of nude mice. Each voxel within the tumor was
modeled as a homogeneous sphere with magnetization m. The magnetic field gradient from each voxel was then
superimposed to form the theoretical magnetic field gradient of the tumor,
which was then fitted to the gradient of the experimental field map, measured
by the acquired phase maps. The results from the x-component of the phase gradient accord well with the known SPIO
concentrations.