Ian Wilson1,2, Gilberto S. Almeida1,2, Andrew M. Blamire2, Kirsten H. Chalmers3, David Parker3, Ross J. Maxwell1,2
1Northern Institute of Cancer Research, Newcastle University, Newcastle Upon Tyne, Tyne and Wear, United Kingdom; 2Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle Upon Tyne, Tyne and Wear, United Kingdom; 3Department of Chemistry, Durham University, Durham, United Kingdom
New cancer treatments are being developed against specific molecular targets, but imaging methods are required to demonstrate drug-target interaction. Fluorinated 19F MR probes are of great interest due to their sensitivity, large chemical shift and minimal endogenous signal. This study evaluates novel fluorinated lanthanide probes in vitro and in vivo. Relaxation results show 100-fold reduction in T1 corresponding to an improvement in signal:noise per unit time of about 10-fold. In vivo results showed limited tumour uptake of the diamide complex, L4Gd, compared to gadoteridol. This strategy is useful for pharmacokinetic evaluation of fluorinated lanthanide complexes.