Lorenzo Tei1, Giuseppe Gugliotta1, Mauro Botta1
1Dipartimento di Scienze dell'Ambiente e della Vita, Universit del Piemonte Orientale "A. Avogadro", Alessandria, Italy
New T1 agents that would take advantage of current 1.5 3 T scanners showing excellent relaxation properties over a broad range of imaging field strengths are object of intense research. Multimeric GdIII agents with medium molecular weight (~3-4 KDa) exhibit improved relaxivity values also at high fields. GdIII di-, tri-, tetra-, hexa- and octameric complexes based on stable and efficient Gd-AAZTA derivatives were synthesised. 1H relaxivity data as a function of magnetic field strength and temperature as well as T1-weighted phantom MR-images at different fields were acquired. These multimeric GdIII contrast agents exhibit improved efficiency for application in both clinical MRI and Molecular Imaging protocols.