Jyoti Lodhia1, Dodie Pouniotis2, Giovanni Mandarano1, Peter Eu, 1,3, Simon Cowell1
1Medical Radiations Research Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia; 2Cancer and Tissue Repair Research Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia; 3Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
MRI is a high spatial resolution non-invasive technique but it has low specificity for targeting explicit pathologies. To achieve a more targeted delivery an MRI contrast agent must be biocompatible, have high chemical stability, be easily functionalised and retain a high net magnetisation value.This study using a highly efficient biocompatible iron oxide nanoparticle with well defined magnetic properties (80emu/g and a T2 of 235.5 mmol-1l s-1) was able to specifically target and image a cancer. The results demonstrated the potential for targeted iron oxide silica nanoparticles in the MRI of specific pathologies.