Mary Charlotte Stephenson1,
1SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Academic Radiology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 3School of Community Healthy Sciences, University of Nottingham, Nottingham, Nottinghamshire
Metabolic profiles in the posterior cingulate cortex (PCC) have been found to be altered due to healthy aging and in many neurodegenerative diseases. The purpose of this study was to use increased spectral resolution and signal, available at higher field, to measure changes in the PCC metabolic profile due to healthy aging and cognitive impairment. Atrophy corrected levels of N-acetyl aspartate, glutamate and aspartate were found to significantly decrease with healthy aging. Levels of phosphocreatine were greatly reduced in patients with cognitive impairment, supporting a crucial role for Creatine Kinase dysfunction in dementia.