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Abstract #1955

White Matter Disruption and Its Relationship with Cognitive Function and Cortical Atrophy in Alzheimers Disease

Hao Huang1, Xin Fan1, Kristin Martin-Cook2, Guanghua Xiao3, Laura Lacritz4, Myron Weiner4, Roger Rosenberg2

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States; 4Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States


The purpose of this study is to find an effective white matter biomarker of Alzheimers disease (AD) which may indicate disease severity and progression. In this study, DTI and T1 weighted images were acquired from 38 subjects (20 AD, 18 controls). We surveyed all white matter tracts by labeling of the ICBM-DTI-81 digital atlas and correlated FA values of individual white matter tracts with cognitive testing score and cortical atrophy map respectively. The correlation analyses show that tracts in the limbic system, namely fornix and cingulum, are the most sensitive tract to cognitive testing scores and cortical atrophy.