Hong Yang1, Xu-ning Zheng2, Yu-feng Zang3, Yi-lei Zhao1, Jue Wang3, Min-ming Zhang1
1Department of Radiology, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, Zhejiang, China; 2Department of Neurology, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, Zhejiang, China; 3State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Using a new biomarker, the amplitude of the low frequency fluct uation (ALFF), the current study is to explore the abnormal spontaneous neural activity of resting state in early PD. Ten early PD patients were compared with eleven gender- and age-matched controls. Data processing was performed using DPARS software. In this study, abnormal ALFF demonstrate that spontaneous neural activity in the resting state is changed in patients with early PD, furthermore, those abnormal neuronal activity should be considered in explaining findings in behavior deficits in early PD. This method is a potential tool to monitor the progression of PD.