Hong Yang1, Xu-ning Zheng2,
Yu-feng Zang3, Yi-lei Zhao1, Jue Wang3,
Min-ming Zhang1
1Department of Radiology, First
Affiliated Hospital of College of Medical Science, Zhejiang University,
Hangzhou, Zhejiang, China; 2Department of Neurology, First
Affiliated Hospital of College of Medical Science, Zhejiang University,
Hangzhou, Zhejiang, China; 3State Key Laboratory of Cognitive
Neuroscience and Learning, Beijing Normal University, Beijing, China
Using
a new biomarker, the amplitude of the low frequency fluct uation (ALFF), the
current study is to explore the abnormal spontaneous neural activity of
resting state in early PD. Ten early PD patients were compared with eleven
gender- and age-matched controls. Data processing was performed using DPARS
software. In this study, abnormal ALFF demonstrate that spontaneous neural
activity in the resting state is changed in patients with early PD,
furthermore, those abnormal neuronal activity should be considered in
explaining findings in behavior deficits in early PD. This method is a
potential tool to monitor the progression of PD.