Andreas Schfer1, Derek VM. Ott1, Almut Focke2, Johannes Schwarz2, Robert Turner1, Sonja A. Kotz1
1Max-Planck-Institute for Human
Cognitive and Brain Sciences,
Parkinson’s disease is the second most common neurodegenerative disorder in humans. It has been previously demonstrated that transverse relaxation times change in Parkinson patients, supporting pathological findings of increased iron content in the substantia nigra. However, relaxation time is a quite indirect measure of changes in iron concentration, and hard to quantify. Recent studies have used phase images to study neurodegenerative diseases, but this method has the disadvantage that field perturbation maps derived from phase data are non-local. Our study demonstrates that local susceptibility maps, directly indexing iron concentration, can be calculated from phase image data in Parkinson patients.